NFL Week 1 Predictions: Latest Odds and Picks Against the Spread

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NFL Week 1 Predictions: Latest Odds and Picks Against the Spread
Justin Edmonds/Getty Images

The start of the 2012 NFL regular season is just a day away, and sports bettors across the country are busy adjusting their power ratings due to what they saw on the gridiron during four rounds of preseason action.

There's a lot of unknown variables when handicapping the first few weeks of any sport, especially in football with all the coaching and player changes that have taken place since the New York Giants beat the New England Patriots in Super Bowl XLVI.

Quarterback Peyton Manning is one of the biggest question marks, as bettors and oddsmakers have struggled to figure out how many points he's worth when creating a line. He still carries some major weight around Las Vegas, with the Denver Broncos holding steady as one-point home favorites (courtesy of SBR Forum) against the Pittsburgh Steelers.

Let's take a closer look at the Week 1 NFL betting odds from a situational standpoint and make some predictions along the way.

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