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Before van Persie, the last time United made a big move in the transfer market was a deadline-day deal for the enigmatic Bulgarian.
In truth, Berbatov never really settled into life at Old Trafford, becoming a periphery figure for much of his time at the club.
His signing gave United tactical flexibility, but they never found a way to get the best out of the languid Berbatov.
During the 2010-11 season, he enjoyed his best spell at the club scoring a league-leading 20 goals, including a memorable five-goal haul against Blackburn and a marvelous hat-trick against Liverpool, capped of with an audacious overhead kick.
Being left out of the match-day squad for the 2011 Champions League Final seemed to cause a rift between himself and Ferguson, and the remainder of his time at the club was spend languishing on the bench.
This summer, United picked up an option to extent his contract by 12 months, hoping to manufacture a return on their initial £30 million investment.
After a rumoured move to Fiorentina collapsed, he returned to London, this time, joining former manager Martin Jol at Fulham.
His hefty price ensures that, despite being more successful on the field, he is ranked lower than the next man on the list.