It's the classic matchup—a high-powered offense (Packers) vs. a dominant defense (49ers). It's the Fox national game on Sunday afternoon (4:25 p.m. EST), but it is more than worthy of a primetime stage like Sunday or Monday night.
The storylines are abundant.
Will Randy Moss be the deep threat the 49ers so desperately need?
Will Nick Perry be the missing link in the Packers defense?
Can Alex Smith do more than manage the game and perhaps look to exploit a vulnerable Packers secondary?
Can Cedric Benson be the run threat the Packers have been missing?
The stories are endless, but this is the game of the week.
Check out our video to see what our NFL experts think of this awesome Week 1 matchup.
We'd love to hear from you in the comments below.