Safest Week 1 NFL Game Predictions

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It’s always safe to assume rookie quarterbacks will struggle in their first real NFL action, but Ryan Tannehill was dealt an especially tough hand, having to open his career in Houston.

Tannehill will have to deal with a Top Five defense, a noisy indoor crowd and the lack of anything resembling an elite receiver to throw to. The Texans will roll to a Week 1 victory, and Tannehill will get a rude introduction to life in the NFL.

Speaking of rookie QBs, Andrew Luck has impressed in the games that don’t matter, but has to open the regular season at Soldier Field against a hungry Bears defense.

Luck inherited the worst team in football, and even if he can hold serve on offense, the Colts' D has no chance of slowing down Matt Forte and Jay Cutler.

Finally, there has been no safer bet the past decade or so than Bill Belichick and Tom Brady, who head to Tennessee in Week 1.

Titans second-year QB Jake Locker will get his first meaningful NFL start, and will do so with a depleted receiving corps and questions in the run game.

The defending AFC champs will have no trouble in this one and are a safe bet to cruise to 1-0. 

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