On Tuesday, 12 English Premier League clubs entered the second round of the newly-named Capital One Cup, which was formerly known as the Carling Cup.
After the matches ended on Tuesday, only 10 EPL clubs advanced to the third round.
The two clubs that failed to survive on the day were Fulham and Stoke.
Fulham's trip to the Hillsborough Stadium to face Sheffield Wednesday resulted in a 1-0 loss after they gave up a penalty early on in the second half.
Gary Madine was the goal scorer for the Owls, who are second in the Championship, as he netted the penalty in the 50th minute.
Fulham, who have scored seven goals in two EPL matches this season, were unable to score at all with a lineup that featured most of their first-team starters.
Stoke's home fortress, the Britannia Stadium, was invaded by League One club Swindon Town.
After 90 minutes, both clubs were even at two goals a piece and went into extra time.
In the extra period, the visitors struck first towards the end of the first 15 minutes of extra time thanks to a goal from Aden Flint.
After Peter Crouch equalized for the home side six minutes later, Swindon yet again went ahead and this time it was for good.
Jim Collins scored the match-winner in the 119th minute for Swindon as they clinched a spot in the third round with a 4-3 win.
As for the other EPL clubs involved in second round play, Aston Villa and QPR handled their business with 3-0 wins both at home.
Other winners on the day from the top flight included West Brom, West Ham, Norwich, Reading, Southampton, Wigan, Swansea and Sunderland.
The only other EPL club to play in the second round is Everton, who will host Leyton Orient at Goodison Park on Wednesday.
The seven EPL clubs competing in Europe will enter the Capital One Cup in the third round.