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The worries in defense continue for Sir Alex Ferguson's side, who will likely be without the injured Rio Ferdinand, Jonny Evans, Chris Smalling and Phil Jones for the second consecutive game.
That means a makeshift defense will once more be a necessity, with Michael Carrick likely to reprise his role in central defense alongside Nemanja Vidic and Antonio Valencia a probability at right-back.
Vidic has exhorted his teammates to be "more clinical" this weekend and believes United will rebound from their disappointing 1-0 loss to Everton at Goodison Park on Monday.
Expect to see more from new signings Shinji Kagawa—who was excellent for large portions of Monday's match—and Robin van Persie, who enjoyed a 23-minute cameo in which he was uncharacteristically ineffective.
Van Persie doesn't often endure long gaps between goals, and when he did get on the ball against the Toffees, he looked his old dangerous self. Whether Ferguson decides to start him in some manner alongside Wayne Rooney at Old Trafford could be quite interesting.
Either way, both new players will be looking to endear themselves to their new fanbase.
To do so, they'll have to cope with the menace of a Fulham side flowing with confidence after a weekend that saw them put five past Norwich City at Craven Cottage.
Fulham manager Martin Jol is still ironing out his new-look side and will likely have to do without last season's leading scorer Clint Dempsey, as the American attempts to force through a transfer away from the club.
The Dutch boss told the club's official website that with the likes of Hugo Rodallega and Mladen Petric up front, it's hard to tell where the goals will come from.
Last weekend they came from Petric, who joined Fulham this summer on a free transfer. Though he's 31, it's looking like a savvy bit of business, as the Croatian was involved in three goals against the Canaries, scoring two and setting up a third.
Jol had to have been pleased with Petric's sparkling debut but is exuding caution ahead of Saturday's tricky fixture. "One swallow does not make a summer," he told the official site. "Hopefully (Petric can score) at more difficult places."
The Croat has made a believer out of former Fulham defender Rufus Brevett, however.
"You couldn’t help but be impressed by Mladen Petric," Brevett wrote in his weekly column for the official website. "It’s important for any striker who joins a new club to get off the mark early on so for him to score two goals and claim an assist on his debut was a very good way to introduce himself."
The task becomes considerably more difficult, however, to recreate that prowess at one of the cauldrons of English football. Fulham came close to obtaining a result in their trip to Old Trafford last season but ended up 1-0 losers.
"Last season [at Old Trafford, United] scored one goal out of nothing," Jol said. “But in the second half we were better and we could have scored—we should have scored—and we should have had a penalty but we didn’t get it so we lost 1-0.
"But hopefully we can play our own game—that is the most important thing. We have to try and play our football and create chances and if you score one or two goals then you’re always in with a chance of a result."
Revenge will certainly be on the minds of the new-look side, and as fortune would have it, they might be heading into Manchester with a perfect storm brewing. A point might not be out of the picture.