Centre Court will be the venue for the 27th encounter between these two esteemed greats. This match surprisingly marks the first meeting for these two at the hallowed lawns dominating the London scene.
The implications surrounding this particular match are titanic.
For the winner, it is a spot in the finals with a golden opportunity to claim the title.
Djokovic's grip on the top ranking is truly in his hands. Win against Federer and he solidifies himself as the domineering figure in men's tennis.
Federer, if able to conquer his pervasive adversary, will be one match away from his seventh Wimbledon title and will recapture the top ranking in the world. A victory at Wimbledon would tie Pete Sampras for the most Wimbledon titles in the open era.
But, let's not get too far ahead of ourselves. Especially in regards to Federer, who undoubtedly is the underdog.
He has lost six out of his last seven matches to the unrelenting Serb. His weaknesses have been brilliantly exploited and strengths severely hindered by Djokovic's depth, movement, variety and tennis IQ.
Federer has been plagued by Djokovic's repertoire and has been unable find a readily working cure to this disease inflicted upon him with abundant volition by Djokovic.
Now, the question with which Federer must find resolution is how to appropriately combat resist this unyielding aggressor.
Let's go through three key things Federer must do to stifle Novak's attack.