There will be several players in 2012 facing what could be make-or-break seasons, while others will be returning from injury or joining a new team.
How each plays will be a key factor in his respective team's fortunes this season.
In the NFL, the quarterback often gets the credit when his team wins and the blame when it loses. As such, many of those signal-callers will appear in this article.
But there are other players who need to meet or exceed expectations, be it bouncing back from a bad season or coming to a new team after signing a lucrative contract.
What follows is a look at the players with the most to prove this season and my feelings on whether they will succeed or fail.