Details: Wednesday, 2:45 p.m. Eastern, Donbass Arena, Donetsk
It's Spanish tiki-taka against the superstar Cristiano Ronaldo (and his more-than-capable supporting cast).
Spain routinely pass opponents into submission with their vaunted possession game, but as yet, La Roja haven't faced a player of Cristiano Ronaldo's caliber.
For all of Spain's possession, their opponents are usually able to create at least a chance or two per match. If there's any player who can capitalize on a single chance, it's Ronaldo.
That's not to say he'll definitely score and Portugal will definitely pull off the upset. But the Portuguese superstar is Europe's best player for a reason, and he should never be counted out.
What's more, Portugal's entire squad is playing well right now. So…
Pick: Upset special. Cristiano Ronaldo bags the winner that further cements his legend, and Pepe turns in an epic defensive performance. 1-0 Portugal.