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A newly promoted side may seem strange on a list of this kind, but the game away at West Ham United comes at a crucial point in the season.
December looks like the most difficult month in the 2012-13 season for Everton as the most crowded month of the season features games against defending Premier League champions Manchester City and Champions League winners Chelsea.
Add to this the importance of the festive season in broader terms, with 15 points up for grabs in a matter of weeks, and the West Ham game suddenly becomes vital.
Sandwiched in between Stoke away and Wigan at home, these games could bring Everton some Christmas joy in an other wise humbug of a month.
How West Ham acclimatise to the Premier League is still yet to be seen, but they've got the quality and experience to make the step-up.
The last time Everton and West Ham met at Boleyn Ground, the game was also played in December and it ended 1-1.
The return fixture also looks important as it comes at the end of the season, in between a Merseyside Derby and the last game of the season away at Chelsea.
Results against West Ham could be important for Everton's European quest.