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As mentioned, Robin van Persie is likely to be spearheading his country's efforts from a central position—although Klaas-Jan Huntelaar may also feature at some stage, dragging Arsenal's front man wider or deeper.
The Dutch team is truly littered with attacking talent, with most attacking berths occupied by world-class talent. Without the ball, each Danish player must be diligent, disciplined and have faith in his fellow teammates to do their jobs.
Any kind of positional indiscipline will allow the Dutch to locate a free man and easily carve through the Danish defence.
Daniel Agger is his country's leader, and performed well at an underachieving Liverpool this season. He has already been anticipating his high-class duel with van Persie, questioning his opposite man's pace and heading ability.
Despite his club's shortcomings, Liverpool were still solid at the back last season, ranking as the third-best defensive unit in the Premier League. Agger was very much part of that, and on paper he one of the best-equipped defenders to stick to and suppress the threat of van Persie.
Yet this may also prove to be his most challenging instruction.
If he looks to his left and sees Simon Poulsen struggling against Arjen Robben, or sees Wesley Sneijder terrorising the Danish midfield ahead of him, he will feel an urge to intervene.
This would leave van Persie lurking in far too much space, and would be exactly what the Netherlands hoped for. Denmark's best hopes of getting a result will come if Agger keeps van Persie quiet.