Sir Alex Ferguson will revamp his squad after losing out on the title this season.
A cull at Old Trafford is likely as the manager tries to shift some of the dead weight out of the club.
The Scotsman will be busy this summer as he looks to revamp a squad capable of competing with nouveau riche Manchester City.
Ferguson recently admitted that United cannot match City's financial clout. Instead, he will have to be smarter in the transfer market, looking for both value and quality.
Newcastle United are a perfect example of how a proper scouting system on the continent can reap massive rewards.
Bleacher Report's Mikhail Turner has taken a look at some of Manchester United's primary transfer targets, all of whom are sure to have fans excited. However, players will need to leave Old Trafford to make way for the team's summer signings.
Here is a look at six players who United should purge from the club's books this summer.
Berbatov's time at United will not be fondly remembered by fans.
Dimitar Berbatov is one of the few players who will definitely not be playing for Manchester United next season.
The Bulgarian's contract expires in the summer and will not be renewed. When United purchased Berbatov from Tottenham, it was seen as a move that would cement the Red Devils' dominance.
In reality, the transfer never quite worked out. Berbatov was not that bad during his spell at Old Trafford; however, it is clear Ferguson never trusted him when it mattered the most.
Berbatov often times found himself on the substitutes' bench during crucial clashes. The emergence of Javier Hernandez last season sealed his fate.
Few United fans will be remiss to see him leave this summer. Berbatov should still be commended for his professionalism this season and not becoming a distraction.
Park Ji-Sung has served United well during his time at the club.
Park Ji-sung is one of those players who will be remembered fondly in Manchester United folklore.
He scored some crucial goals, put in some vital performances and offered versatility to Ferguson. His energy and fitness levels are legendary and made up for his lack of talent.
This season has been a bit different for Park. He has looked like a weary boxer who has been in one-too-many battles. It may be best for United to part way with the Korean this summer.
Park is obviously a player in decline. Ferguson would be better served by letting some of the younger players fill in for Park next season.
It would also better suit Park to be playing more regularly as well. At 31 years old, this is probably the last chance he has to find first-team football.
Ashley Young has come under criticism during his time at Old Trafford
It is time for the end of the Ashley Young era at Manchester United.
He was never really good enough for the Red Devils, and his disjointed and underwhelming performances have not won over the United fans.
His diving has also done little to endear himself to the public.
Young still has value so United will recoup a fair share of what they paid for him. There are plenty of players they can get for cheaper to replace him.
Nani and Antonio Valencia proved this season they were first choice when healthy. It is hard seeing Young being able to displace either one.
Jonny Evans has never been able to fulfill his potential at Manchester United
There was a time when transfer gossip had Barcelona interested in signing Jonny Evans. That seems outlandish now.
It is not that Evans is awful, but he was supposed to be so much better. For whatever reason, his development has leveled off.
With five centre-backs on the payroll, Ferguson will probably let one leave. Phil Jones and Chris Smalling are the defensive partnership of the future, and both offer versatility, so they are not going anywhere.
Nemanja Vidic seems to constantly be linked with a move away from Old Trafford, while Rio Ferdinand will continue to see a reduced role.
It is Evans, though, who should be shown the exit. Not only could he fetch a decent price in the transfer market but losing Evans would not be a significant loss of Ferguson should the other four remain at United.
Injuries have prevented Anderson from having a bigger role at Manchester United
Anderson could be the difference maker in the Manchester United midfield. He has shown glimpses and flashes of being an excellent player.
He also can never seem to stay healthy when he is playing well. Anderson has basically become another Owen Hargreaves.
Ferguson is going to revamp his midfield this summer, and it is hard to see where Anderson is going to fit into these plans. If a team is willing to pay for the Brazilian, United would be foolish not to accept it.
There is the risk that he manages to stay healthy somewhere else, but these is also a real possibility that he is nothing more than a midfield version of Jonathan Woodgate.
Selling Anderson is a risk. One that is probably worth taking.
Federico Macheda will always be remembered for scoring the title winner against Aston Villa
Federico Macheda scored one of the most important and memorable goals in Premier League history for Manchester United.
Apart from that he has contributed literally nothing else to the Red Devils. Here is a brief summary of the Italian's career:
Aston Villa goal, reserve team football, unimpressive loan spell in Italy, unimpressive loan spell at QPR and injury.
Macheda is never going to make the grade at Old Trafford. It is best for all parties involved if he finally moves on.