With recorded knockouts against prominent boxers such as Ricky Hatton and Victor Ortiz, among several others, many are predicting Mayweather to make Miguel Cotto No. 27 on his list of KOs.
Mayweather has done it so many times before, so why wouldn't he be able to do it again?
First things first, Mayweather is a very strong defensive boxer.
This helps with delivering knockouts because it wears down an opposing boxer, while spending a good deal less energy yourself. Not only does the physical stamina leave the opposition after dozens upon dozens of his punches are blocked, but it wears away at the mental stamina, as well.
Nothing get's a fighter's mind tossed quicker then realizing he's bloody, exhausted and his opponent is bouncing around clean.
Cotto has a reputation for having weak stamina and being a bleeder, so Mayweather's superb defense will be a big step en route to another "Money" knockout.
Secondly, Cotto has reverted back to a more unorthodox stance.
Cotto had a very good, closed stance at one point, but a few changes in his coaching personnel and it seems he's back to his formative years in the ring. He stands square to his opponent with his hands low while leaning forward, almost as if he's leading with his head.
You would think after the successful professional career Cotto has enjoyed, he would've learned leading with your head enables the opposition to knock you out.
Mayweather is a very accurate, quick and powerful puncher that has the experience and the pedigree to notice this weakness immediately and will build off of it.
Keep the head back Cotto, or it will get knocked off.
Third, as just mentioned, Mayweather is an extremely quick and accurate striker. He has excellent control over ever punch and combo he lands. Very rarely will he just go on a blind fury in hopes to land a lucky blow, everything is thought out and calculated.
Most importantly, though, Mayweather has a devastating uppercut.
If Cotto is going to try and use is unorthodox, forward-lean stance, Mayweather is going to try and knock Cotto's chin clean off with a few uppercut combos.
Also, Mayweather has never known a professional defeat.
Cotto has been knocked out twice, once by Manny Pacquiao in 2009 and once by Antonio Margarito in 2008.
We don't know what it takes to get Mayweather on the canvas. There's no history of him getting knocked out. Nobody that Cotto can talk to and train with in order to get some insight on how to get to Maywether's soft spot because nobody has found it yet.
This sort of success brings with it tested confidence that one cannot possess naturally or try to force. A confidence that has often been perceived as arrogance from Mayweather, but confidence nonetheless.
The final point is Mayweather's last fight was against a prime contender in Victor Ortiz.
Mayweather looked like he was on the poor end of the fight for a second before a foolish headbutt and misplaced apologies cost Ortiz the fight.
Scandal aside, it was still a very good fight between two strong opponents.
Cotto on the other hand, avenged a loss to Margarito.
Margarito passed his prime a while ago and has lingering aliments from an eye injury that was caused by Cotto himself. Many would say that Margarito should never have taken the fight and I see it as less then an accurate test for Cotto to go through.
It's going to be a big change of pace going from Margarito to Mayweather, and it's all up in the clouds if Cotto can make the change.