The bout will likely serve as the co-main event on a card that's also expected to host a championship bout in the light-heavyweight division when Jon Jones attempts to defend his title for a fourth time against PRIDE FC legend Dan Henderson.
Kongo and Nogueira are both coming off of stoppage losses in their most recent bouts.
Kongo was knocked out by Mark Hunt at UFC 144. Prior to that, the Frenchman had not suffered a loss since 2009.
Big Nog was submitted for the first time in his career at UFC 140 by current No. 1 contender Frank Mir. Nogueira has not found the success he wanted in the UFC, as he holds a modest 4-3 record in the organization.
UFC 149 is also expected to host an interesting welterweight matchup between Thiago Alves and Yoshihiro Akiyama.