Las Vegas oddsmakers have established the Tigers as -180 home favorites, while the total stands at 8.5, but is currently receiving downward pressure in the betting market.
Detroit's high-powered offense managed to score just 12 runs in dropping three of four home games against the Texas Rangers, as the club looks to win its first game following an off day in three chances.
Tigers starting pitcher Max Scherzer (1-1, 7.98 ERA) is starting to put things together entering his fourth outing of the year, coming off a 4-3 road win over the Kansas City Royals last time out. He gave up three runs and seven hits in six frames in that effort.
The power right-hander has registered a perfect 4-0 record and 2.00 ERA in four career starts versus the Mariners, including a 2-0 mark and 2.08 ERA in two outings last year. He has limited Mariners outfielder Ichiro Suzuki to just two hits in 12 at-bats (.167) against him.
Sports bettors will find that the Tigers are 6-1 versus southpaw starters this year, while the "under" is 6-1 in those contests.
Seattle finished up a nine-game home stand with a 3-6 record, as it looks to snap a four-game losing streak after enjoying an off day on Monday. The Mariners need to get things going offensively, with six of their seven wins coming when scoring four or more runs.
Jason Vargas (2-1, 2.84 ERA) has been solid in all four starts this year, with the Mariners alternating wins and losses in each of them. He came away with a 4-1 home win over the Cleveland Indians last time out, giving up just a single run and four hits over seven innings.
The left-hander will be making his fourth lifetime start against the Tigers, coming in with an 0-1 record and 5.87 ERA, which includes giving up six runs and eight hits in a 6-1 loss in his only start at Comerica Park on July 3, 2010.
The Mariners are 4-11 in Vargas' last 15 starts as a road underdog of +151 to +200, while the "over" is 6-2 in the last eight series meetings in Detroit overall.
Weather forecasts suggest partly cloudy skies and game-time temperatures in the mid-40s, with gusty winds of 15-25 mph out of the northwest (out to center).