It's the greatest rivalry in all of sports, and the first series of this historic rivalry will begin on Friday afternoon.
Going into their first showdown of 2012, the teams enter on different paths.
The Yankees come in at 7-6 and have been playing decent baseball. They come off a split at home against the Minnesota Twins.
The Red Sox, on the other hand, come in at 4-8 and are really struggling. They come off getting hammered by the American League champion Texas Rangers in their own building.
Now it's time to take a look at the three-game series that will take place at Fenway Park.