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It's been nearly two years since Peyton Manning and Tom Brady squared off in a regular season game, and this matchup brings a whole new era to the rivalry.
Manning will be with a new team, and at this point in the season, he should have a pretty good feel for the Denver Broncos offense. Depending on how the young wide receivers on the roster develop while under Manning, the Broncos could sport one of the most potent offenses in the league.
Of course, they'll need to be potent to keep up with the offense that the New England Patriots will trot out onto the field. There may not be a more dangerous offense in the league than New England with Wes Welker, Brandon Lloyd, Aaron Hernandez and Rob Gronkowski.
One aspect of this game to watch closely is the impact that Denver's defense has on the game. This is one of the more underrated units in the league, and if they can consistently pressure Brady, it could be the deciding factor in the game.
Final Score: Broncos 28, Patriots 24
This is going to be the first game of the season that Manning rallies his new team on a late drive that results in a victory. It will show the rest of the league that the Broncos are a legitimate contender.