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Above all else, Manning is a control freak.
That doesn't just mean that he's constantly calling audibles and directing traffic at the line. He wants complete control of the offense, of offensive philosophy and strategy, and at times, of the locker room itself.
Keep in mind, when Manning was first shopping himself to teams in free agency, he specifically surveyed trusted sources to vouch for Miami Dolphins wide receiver Brandon Marshall before considering Miami as a landing spot as reported by the Denver Post via Twitter. Manning doesn't like divas or troublemakers, never has.
That same fact is largely why I believe Manning was ultimately disinterested in joining the 49ers, who boast two diva wideouts in Randy Moss and Michael Crabtree in their locker room.
Manning wants to run the offense his way and wants the team to function accordingly. In Denver, expect Manning to have a say in which sets and personnel the Broncos roll with. By proxy of this power, don't be surprised if the Broncos start making free agency bids for Jeff Saturday, Dallas Clark or Joseph Addai.