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Given that the Giants have (hopefully) addressed all of their major needs by now, the attention in the final rounds has to be focused on adding depth. The safety position depends on Deon Grant's free-agency status, the wide receiver position depends on Mario Manningham and the tight end position could still use another body.
Drafts are typically won or lost in the middle to late rounds. Evaluating these players is a grind, and Jerry Reese and his crew have done a terrific job over the years.
Best Case(s): The Giants like to go defense late in drafts and help their special teams unit. They did an amazing job of this last season, and I expect them to do the same this year. With the final three picks, the base case scenario I can envision is drafting a safety, defensive end and tight end. Every one of those positions would do well by having another body compete for a position in training camp.
Worst Case(s): The worst case I can see for these picks is if the Giants have not addressed their major needs and are attempting to fix problems with late-round gems. I'm not saying this cannot be done, but it goes without saying you are more likely to improve the offensive line with first and second day picks.
The Giants were able to put together a dominant offensive line with mostly late-round picks and Chris Snee in the past, but they should not bank on that happening again.
That said, pretty much all picks are a crap shoot. I have learned over the last several years to simply trust whatever Jerry Reese and his team end up with. It has not always worked, but his picks have panned out more often than not.