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Sir Alex Ferguson has shown different formations at various times in his career, but 4-4-2 has been a key part of the manager's arsenal.
With a player like Wesley Sneijder in the mix, 4-3-3 may be the best bet, especially if Tom Cleverley is to play as well.
Manchester United would still have its great depth in all positions and could revert to its regular 4-4-2, or even a 4-2-3-1 with Carrick and Darren Fletcher behind Sneijder.
Fans may point out the omission of Javier Hernandez or Danny Welbeck, but they would still get a great amount of games in the team's usually long season.
Hernandez would be the main option behind Rooney and provide something different in the process. Welbeck would still be used in his preferred position up front, but could be another choice on the wings besides Ashley Young.
In midfield, Fletcher and Anderson could fit in alongside either playmaker, and Fletcher especially could fit in as the defensive midfielder if really necessary.
Phil Jones could do that job as well, and as a result, Ferdinand or Chris Smalling would step in to his position in defense.