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Juan Martin Del Potro is a dangerous player for the top four seeds.
The general consensus among tennis fans is that the Argentine, when on top form, is the best equipped player outside of the "big four" to be able to win a Grand Slam on a hard court.
He was superb on the clay in Seville, as he pushed Rafael Nadal all the way in the Davis Cup final.
Although he suffered a devastating defeat then, there were clearly promising signs that he is returning to his very best form and that the Australian Open is one of the two majors that the Argentine will be targeting to add to his one Grand Slam victory thus far, the 2009 US Open.
He begun the tournament slowly, by taking four sets to get past Frenchman Adrian Mannarino before a scrappy three-set win against Blaz Kavcic.
In the third round, Del Potro ramped his game up against Taiwanese player Lu Yen-hsun and strolled to a three-set victory, dropping just five games.
The signs are ominous for the German Kohlscreiber, who will struggle against Del Potro's game, which should have too much range and power in this one.
The German did pick up an impressive win against Juan Monaco in the first round in five sets, but the road should end here as we finally see Del Potro enter the necessary form to topple two of the best four players in the world and claim a Grand Slam.
The Argentine holds a 4-0 record against his opponent and has only dropped one set in that time, five years ago in the first meeting.
I predict a straight-sets victory for Del Potro.