The NFL Draft will never be an exact science. Getting the first pick could end with a team grabbing a player like Peyton Manning and revitalizing a franchise, or picking someone like JaMarcus Russell who just wasn't cut out for the NFL.
But the first pick isn't needed to get a great player. In fact, fantastic players are available in every round (just ask Tom Brady).
So, which players are destined to makes waves once they set foot in the league?
There are quite a few safe grabs in the first round, and all of these guys should have great NFL careers.