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Teams that have had success throwing the football against this 49ers squad have done so with short and intermediate routes with slot receivers and tight ends, primarily.
To that end, the health and production of Lance Moore is huge in this game. If he is able to play—and play at a high level—the Saints should work the ball down the field almost at will against this defense.
Those short and intermediate throws will eventually open the deeper passing game against one-on-one coverage. But it first has to start with success with the short stuff.
This would also work well because the Niners are probably going to come out jacked up and have some success early in the game getting to Drew Brees. Thus, the short pass would act as a pressure-beater.
Finally, Lance Moore is the Saints' best quick hitch/screen receiver. And that is a route concept that works well against this off-coverage 49ers' secondary.