The former UFC heavyweight champion is going to have his hands full with ex-Strikeforce champion Overeem, who is making his UFC debut.
Both men have a lot to prove in the Octagon tonight. Both want to make a big statement.
Only one can make that statement.
Lesnar has been out of action since October of last year when he suffered an ugly loss to Cain Velasquez. He lost the championship in the fight.
The loss caused many to question Lesnar's ability to take a punch after getting crushed by a fighter he outweighed by nearly 35 pounds.
Before he could respond to critics, Lesnar was taken out of commission due to complications with his diverticulitis.
Who will win tonight's fight?
This will be his first fight back since the loss. He needs to step up and make a big statement. People want to see him prove he can take on somebody with elite striking ability.
Alistair Overeem has just that.
The kickboxing specialist is not only one of the best strikers in the weight class, but he is also likely one of the best in all of mixed martial arts.
Not much is known about Overeem for most UFC fans.
He has crushed competition outside of the UFC. He hasn't lost in his last 11 fights.
He's the only fighter to ever hold the Strikeforce Heavyweight Championship.
Tonight Lesnar will be stepping into the ring with a fighter who is not only physically superior, but also mentally superior.
While Lesnar has doubters, Overeem does not. He has been on a tear and already has his eyes set on the UFC Heavyweight Championship.
Lesnar could make a big statement with his return if he walked away with a win.
That's not going to happen.
In fact, he'll be lucky to make it out of the first round against an opponent who outmatches him in almost every way imaginable.